Talk:Diphenhydramine

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Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Diphenhydramine.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Using PMID: 23357028 (Citatin [61]) as a source for potentially wrong (in the case of Diphenhydramine) many listed pharmacological binding affinities in this wiki

I think this is problematic issue as this citation for this paper, (PMID: 23357028) upon inspection, it is simply reviewing an extremely wide variety of antihistamanergic drugs, in the paper no actual claims are made that diphenhydramine has any direct activity at dopamine 2 receptors or 5-HT2A receptors, i think any entry on this wiki page using this paper as a citation should be reviewed. Databoose43 (talk) 11:01, 4 February 2024 (UTC)[reply]

Anxiety

I used Diphenhydramine for anxiety for a long time, and it works, although its not approved to treat Anxiety. Of course, this is an off label use, but it works. My friends also tell me how much it helped them, so I added a sub section under Medical uses for this. There are many other anti histamines, and they are meant to treat anxiety. For example Hydroxyzine. But Hydroxyzine requires a prescription, while Benadryl can be purchased without a prescription. A prescription can be difficult to get sometimes, and when you need something quick and easy to get to help you relax, Benadryl is a good temporary choice. I was hoping if somebody can please help improve the article by adding more details about Diphenhydramine's ability to help with Anxiety. It also has antidepressant properties, which is mentioned somewhere in the article, but there's not enough details it seems.

For now, I only added the anxiety sub section. Noam Atadgy (talk) 02:41, 8 November 2024 (UTC)[reply]

The sources you added are not reliable for medical content, WP:MEDRS, especially for treating a common disorder, such as anxiety. Your edit and explanation here were more about personal experience, which is WP:OR.

I rewrote the 'Anxiety' section with this edit. See that source with a specific explanation about the use of Benadryl for anxiety - it is not approved by the FDA, so should not be stated in the article as a common, clinically-valid use. Zefr (talk) 20:04, 9 November 2024 (UTC)[reply]